GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9309473 | 1 | rs7585004 | chr2:73666645 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.7 | 8.7E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs7586463 | chr2:73798476 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.53 | 1.69E-5 | Metabolite levels |
| THYM | cis | rs2143950 | 1 | rs75889859 | chr14:35539054 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.16 | 6.96E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs75889859 | chr14:35539054 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 5.01 | 2.56E-6 | Atopic dermatitis |
| THYM | cis | rs758970 | 1 | rs758970 | chr9:129194773 | FAM125B | chr9:129089128-129273699:+ | 0.41 | 4.18 | 6.43E-5 | Obesity-related traits |
| THYM | cis | rs7589728 | 1 | rs7589728 | chr2:88518440 | THNSL2 | chr2:88469835-88486145:+ | -0.5 | -4.23 | 5.34E-5 | Plasma clusterin levels |
| THYM | cis | rs7591472 | 1 | rs7591472 | chr2:201889751 | PPIL3 | chr2:201735680-201753999:- | -0.88 | -10.24 | 5.04E-17 | Triptolide cytotoxicity |
| THYM | cis | rs11971779 | 1 | rs75919582 | chr7:139054919 | C7orf55 | chr7:139025897-139030539:+ | -0.21 | -4.54 | 1.63E-5 | Diisocyanate-induced asthma |
| THYM | cis | rs3820928 | 1 | rs7592387 | chr2:227777095 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.54 | 1.63E-5 | Pulmonary function |
| THYM | cis | rs9309473 | 1 | rs7594511 | chr2:73681639 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.56 | 1.53E-5 | Metabolite levels |
| THYM | cis | rs60843830 | 1 | rs7595075 | chr2:264019 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs7608910 | 1 | rs7596362 | chr2:61204688 | C2orf74 | chr2:61372243-61391964:+ | 0.39 | 4.35 | 3.4E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THYM | cis | rs7597155 | 1 | rs7597155 | chr2:69985435 | GMCL1 | chr2:70056818-70106727:+ | 0.14 | 4.98 | 2.86E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| THYM | cis | rs9309473 | 1 | rs7598396 | chr2:73652628 | ALMS1P | chr2:73872046-73912692:+ | 0.59 | 4.56 | 1.53E-5 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs7598419 | chr2:73798223 | ALMS1P | chr2:73872046-73912692:+ | 0.61 | 4.61 | 1.27E-5 | Metabolite levels |